Mechanisms
Mechanisms: 6 articles from Peptides Facts. Evidence-led reference on research peptides.
Selank: Proposed Anxiolytic Mechanism and the State of the Evidence
Selank is a tuftsin analogue registered as an anxiolytic in Russia and nowhere else. Its proposed mechanism is indirect modulation of GABAergic signalling, and the literature supporting it is real, substantial and genuinely difficult to appraise from outside.
MOTS-c: A Peptide Written by the Mitochondrial Genome, and the AMPK Mechanism Proposed For It
MOTS-c is a 16-amino-acid peptide encoded inside the mitochondrial genome rather than the nuclear one. That single fact makes it a different kind of molecule from almost every other peptide discussed in this field, and it shapes the mechanism proposed for it.
Semaglutide: The GLP-1 Receptor, and Three Modifications That Made a Weekly Drug
Native GLP-1 survives about two minutes in circulation. Semaglutide survives about a week. The engineering that produced that difference is the clearest worked example of peptide drug design in the literature.
GHK-Cu: How a Three-Residue Peptide Carries Copper, and What That Explains
Glycyl-histidyl-lysine binds copper(II) with unusually high affinity. Most of the compound's reported activity is attributed to that single property — and most of its literature comes from one research group.
TB-500 and Thymosin β4: The Mechanism, and Why the Two Are Not Interchangeable
Thymosin β4 is a 43-residue actin-sequestering peptide with a well-characterised cellular function. TB-500 is a shorter synthetic construct sold under its name. Conflating them distorts most of what is written about both.
BPC-157: What the Evidence Says About Its Mechanism of Action
A pentadecapeptide derived from a gastric protein, studied largely in rodent models. Here is what is actually established about how it behaves, and where the evidence stops.